Lateral inhibition of Notch signaling in neoplastic cells
نویسندگان
چکیده
منابع مشابه
Lateral inhibition of Notch signaling in neoplastic cells
During normal development, heterogeneous expression of Notch ligands can result in pathway suppression in the signal-sending cell, a process known as lateral inhibition. It is unclear if an analogous phenomenon occurs in malignant cells. We observed significant induction of Notch ligands in glioblastoma neurospheres and pancreatic carcinoma cells cultured in low oxygen, suggesting that this phe...
متن کامل9-cis-Retinoic Acid and 1,25-dihydroxy Vitamin D3 Improve the Differentiation of Neural Stem Cells into Oligodendrocytes through the Inhibition of the Notch and Wnt Signaling Pathways
Background: Differentiating oligodendrocyte precursor cells (OPCs) into oligodendrocytes could be improved by inhibiting signaling pathways such as Wnt and Notch. 9-cis-retinoic acid (9-cis-RA) and 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) can ameliorate oligodendrogenesis. We investigated whether they could increase oligodendrogenesis by inhibiting the Wnt and Notch signaling pathways.Methods: Co...
متن کاملDelta-Notch signaling and lateral inhibition in zebrafish spinal cord development: Correction
Correction There is an error in the Materials and methods section of our recent manuscript [1]. In our description of BrdU detection , the phrase "the embryos were treated with 2 N NaOH for 1 hr" should read as "the embryos were treated with 2 M HCI for 1 hr". We regret the mistake. The original article can be viewed at [ Verbatim copying and redistribution of this article are permitted in any ...
متن کاملDynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition.
The organization of bristles on the Drosophila notum has long served as a popular model of robust tissue patterning. During this process, membrane-tethered Delta activates intracellular Notch signaling in neighboring epithelial cells, which inhibits Delta expression. This induces lateral inhibition, yielding a pattern in which each Delta-expressing mechanosensory organ precursor cell in the epi...
متن کاملLateral Inhibition through Delta-Notch Signaling: A Piecewise Affine Hybrid Model
Biological cell networks exhibit complex combinations of both discrete and continuous behaviors: indeed, the dynamics that govern the spatial and temporal increase or decrease of protein concentration inside a single cell are continuous differential equations, while the activation or deactivation of these continuous dynamics are triggered by discrete switches which encode protein concentrations...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2014
ISSN: 1949-2553
DOI: 10.18632/oncotarget.2762